Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212

@article{Kar1992EffectOC,
  title={Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212},
  author={Louis D. Kar and Peter A. Rittenhouse and Patricia A. O'Connor and Thomas Palionis and Cynthia L Bethea},
  journal={Biological Psychiatry},
  year={1992},
  volume={32},
  pages={258-269}
}
This study was undertaken to examine whether several of the hormones that can be released by activation of serotonin receptors will be affected by long-term cocaine administration. Male rats received cocaine injections (15 mg/kg, IP) twice daily for 7 days. Forty-two hr after the last cocaine injection, the rats were challenged with increasing doses (0, 1, 5, 10 mg/kg, IP) of the 5-HT1/5-HT2 agonist MK-212 (6-chloro-2-[1-piper-azinyl]-pyrazine). The following observations were made: (1) cocaine… Expand
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