Effect of cobalt-mediated Toll-like receptor 4 activation on inflammatory responses in endothelial cells

Abstract

Cobalt-containing metal-on-metal hip replacements are associated with adverse reactions to metal debris (ARMD), including inflammatory pseudotumours, osteolysis, and aseptic implant loosening. The exact cellular and molecular mechanisms leading to these responses are unknown. Cobaltions (Co2+) activate human Toll-like receptor 4 (TLR4), an innate immune… (More)
DOI: 10.18632/oncotarget.13260

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