Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases.

@article{Luo2005EffectOC,
  title={Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases.},
  author={Li Luo and Alain Petit and John Antoniou and David J. Zukor and Olga L. Huk and R. W. Liu and Françoise M Winnik and Fackson Mwale},
  journal={Biomaterials},
  year={2005},
  volume={26 28},
  pages={5587-93}
}
Previous reports have suggested that the imbalance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) activity may contribute to prosthetic loosening. However, the mechanisms controlling these enzymes in the periprosthetic environment is unknown. We examined the effect of Co2+ and Cr3+ ions on the expression of genes encoding MMP-1, one of the principal proteinases capable of degrading native fibrillar collagens in the extracellular matrix (ECM), its… CONTINUE READING