Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda

@article{Mermin2004EffectOC,
  title={Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda},
  author={J. Mermin and J. Lule and J. P. Ekwaru and S. Malamba and R. Quick},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={1428-1434}
}
  • J. Mermin, J. Lule, +2 authors R. Quick
  • Published 2004
  • Medicine
  • The Lancet
  • BACKGROUND Prophylaxis with co-trimoxazole (trimethoprim-sulphamethoxazole) is recommended for people with HIV infection or AIDS but is rarely used in Africa. We assessed the effect of such prophylaxis on morbidity, mortality, CD4-cell count, and viral load among people with HIV infection living in rural Uganda, an area with high rates of bacterial resistance to co-trimoxazole. METHODS Between April, 2001, and March, 2003, we enrolled, and followed up with weekly home visits, 509 individuals… CONTINUE READING
    344 Citations

    Paper Mentions

    Interventional Clinical Trial
    Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis pneumonia and other infections in HIV positive patients with low… Expand
    ConditionsAntibiotic Side Effect, HIV-1-infection, Opportunistic Infections, (+2 more)
    InterventionDrug
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    Both antiretroviral therapy (ART) and prevention of opportunistic infections (OIs) have been associated with significantly decreased mortality in HIV-infected individuals… Expand
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