Effect of clonidine on lidocaine clearance in vivo: a microdialysis study in humans.

@article{Kopacz2001EffectOC,
  title={Effect of clonidine on lidocaine clearance in vivo: a microdialysis study in humans.},
  author={Dan J. Kopacz and Christopher M. Bernards},
  journal={Anesthesiology},
  year={2001},
  volume={95 6},
  pages={1371-6}
}
BACKGROUND The addition of clonidine to local anesthetics has been shown to prolong both peripheral and central neuraxial local anesthetic blocks. Whether clonidine prolongs local anesthetic block by a pharmacokinetic effect or a pharmacodynamic effect is unclear. By directly measuring lidocaine tissue concentrations at the site of injection in the presence and absence of clonidine, this study was designed to address this question. METHODS Microdialysis probes were placed adjacent to the… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…