Effect of clodronate treatment on established bone loss in ovariectomized rats.

@article{Kippo1998EffectOC,
  title={Effect of clodronate treatment on established bone loss in ovariectomized rats.},
  author={Katriina Kippo and Ritva Hannuniemi and Lauren Lauren and Zhiqi Peng and P. Kuurtamo and Tiina Virtamo and Pernilla Isaksson and Travis Osterman and H. Kalervo V{\"a}{\"a}n{\"a}nen and Richard Sellman},
  journal={Bone},
  year={1998},
  volume={23 4},
  pages={333-42}
}
The ability of clodronate to prevent bone loss and weakening of bone strength was studied in adult rats with established osteopenia. Six-month-old female Sprague Dawley rats were randomized into 13 groups. One group was killed at the start of the study, nine groups were ovariectomized (ovx), and three groups sham-operated (sham). After 4 months, the ovx rats were given either clodronate or vehicle subcutaneously (s.c.), once a week for 3 or 6 months, the cumulative doses of both dosing regimens… CONTINUE READING