Effect of clavulanic acid on the anti-pseudomonal activity of ticarcillin

Ticarcillin replaced carbenicillin in the treatment of infection by Pseudomonas aeruginosa many years ago. More recently, clavulanic acid has been added to ticarcillin to improve its activity. Clavulanic acid binds to the bacterial plasmid-mediated beta-lactamase that inactivates ticarcitlin (1). It may bring about the opposite effect, however. Ctavulanic… (More)