Effect of citalopram on ouabain-induced arrhythmia in isolated guinea-pig atria.

The effect of citalopram (CTP) a selective serotonin reuptake inhibitor agent was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. CTP (2-32 microg/ml) produced a dose-dependent decrease in the force of contractions (7-62%), and in the rate of contractions (11-72%). Pre-administration of the atria with CTP inhibited… (More)