Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation.

@article{Sadzuka1992EffectOC,
  title={Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation.},
  author={Yasuyuki Sadzuka and Tetsuaki Shoji and Yoshio Takino},
  journal={Biochemical pharmacology},
  year={1992},
  volume={43 8},
  pages={1872-5}
}
Increases in lipid peroxide in kidneys of rats treated with cisplatin were examined in relation to decreases in the activities of Cu,Zn-superoxide dismutase (Cu,Zn-SOD), Mn-SOD, glutathione peroxidase (GSHpx), glutathione S-transferase (GST) and catalase. The activities of catalase, GSHpx and GST in the kidney and the liver were significantly decreased after cisplatin administration. The decrease of GST activity in the kidney was 87.3%, this was the largest decrease among these enzymes in the… CONTINUE READING
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