Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats.

@article{Bushinsky2006EffectOC,
  title={Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats.},
  author={David A. Bushinsky and K Laplante and John R. Asplin},
  journal={Kidney international},
  year={2006},
  volume={69 9},
  pages={1586-92}
}
Idiopathic hypercalciuria is the most common metabolic abnormality in patients with nephrolithiasis. Through successive inbreeding, we have developed a strain of rats whose urine calcium (UCa) excretion is approximately 8-10-fold greater than that of control rats and who spontaneously form kidney stones. We have termed these rats genetic hypercalciuric stone-forming (GHS) rats. The physiology of the hypercalciuria in the GHS rats closely parallels that of man. We have recently shown that the… CONTINUE READING

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