Effect of cimetidine and ranitidine on cardiovascular drugs.

  title={Effect of cimetidine and ranitidine on cardiovascular drugs.},
  author={Anne M Baciewicz and Frank A Baciewicz},
  journal={American heart journal},
  volume={118 1},
A compilation of drug interactions between H2 antagonists and cardiovascular drugs is found in Table I. Cimetidine's potency, lipophilicity, and affinity for binding to the P-450 cytochrome system can probably be attributed to the drug interactions that have been identified with the H2 antagonists. The mechanism for most cimetidine drug interactions is inhibition of hepatic metabolism. There is conflicting evidence regarding significance of altered liver blood flow for both cimetidine and… CONTINUE READING