Effect of cimetidine and antacid on gastric microbial flora.

  title={Effect of cimetidine and antacid on gastric microbial flora.},
  author={R A Snepar and G A Poporad and Joan M. Romano and W D Kobasa and Donald Kaye},
  journal={Infection and immunity},
  volume={36 2},
The effect of a standard regimen of cimetidine on the gastric flora of 20 male volunteers was studied in a double-blind manner and compared with the effects of a standard antacid regimen. Postprandial microbial titers in gastric aspirates were significantly higher at 4, 8, and 16 weeks of therapy in subjects taking antacids and at 4 weeks in subjects taking cimetidine when compared with their pretreatment titers. Although not significant, there was a tendency for fasting microbial titers to be… CONTINUE READING
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