Effect of chronic uraemia on skeletal muscle metabolism in man.

@article{Thompson1993EffectOC,
  title={Effect of chronic uraemia on skeletal muscle metabolism in man.},
  author={Campbell Thompson and Graham J. Kemp and Doris J. Taylor and John G. G. Ledingham and George K. Radda and Bheeshma Rajagopalan},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1993},
  volume={8 3},
  pages={218-22}
}
Fatigue and lethargy, common symptoms in uraemia, have been attributed to many factors. To assess possible bioenergetic contributions to this, we examined the forearm muscle of five patients in end-stage renal failure using 31P-magnetic resonance spectroscopy. There was a small increase in the ratio of intracellular inorganic phosphate to ATP in resting muscle, suggesting an increased cytosolic phosphate concentration. During exercise, increased phosphocreatine breakdown was accompanied by… CONTINUE READING

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The initial rate of PCr resynthesis was not significantly decreased , but when account was taken of the high cytosolic ADP concentration ( which drives mitochondrial oxidative ATP synthesis ) the calculated maximum oxidative capacity was significantly reduced in the uraemic subjects .
This resulted in increased phosphocreatine depletion and increased glycolytic ATP production during exercise and there was partial compensation of the mitochondrial abnormality by increased ADP concentration .
This resulted in increased phosphocreatine depletion and increased glycolytic ATP production during exercise and there was partial compensation of the mitochondrial abnormality by increased ADP concentration .
The initial rate of PCr resynthesis was not significantly decreased , but when account was taken of the high cytosolic ADP concentration ( which drives mitochondrial oxidative ATP synthesis ) the calculated maximum oxidative capacity was significantly reduced in the uraemic subjects .
FatigueNo subtypeLethargy
Fatigue and lethargy , common symptoms in uraemia , have been attributed to many factors .
During exercise , increased phosphocreatine breakdown was accompanied by rapid intracellular acidification and an increase in calculated lactic acid accumulation in the muscle of the uraemic subjects , suggesting glycolysis dominating over oxidative phosphorylation as a source of ATP .
During exercise , increased phosphocreatine breakdown was accompanied by rapid intracellular acidification and an increase in calculated lactic acid accumulation in the muscle of the uraemic subjects , suggesting glycolysis dominating over oxidative phosphorylation as a source of ATP .
LethargyNo subtypeFatigue
Fatigue and lethargy , common symptoms in uraemia , have been attributed to many factors .
There was a small increase in the ratio of intracellular inorganic phosphate to ATP in resting muscle , suggesting an increased cytosolic phosphate concentration .
There was a small increase in the ratio of intracellular inorganic phosphate to ATP in resting muscle , suggesting an increased cytosolic phosphate concentration .
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