Effect of chronic treatment with dizocilpine (MK-801) on the behavioral response to dopamine receptor agonists in the rat

@article{Dallolio1992EffectOC,
  title={Effect of chronic treatment with dizocilpine (MK-801) on the behavioral response to dopamine receptor agonists in the rat},
  author={Rossella Dall'olio and Ottavio Gandolfi and Nicola Montanaro},
  journal={Psychopharmacology},
  year={1992},
  volume={107},
  pages={591-594}
}
The D2 or D1 dopamine receptor blockers (−)-sulpiride or SCH 23390 antagonized, in a dose dependent manner, the hypermotility induced by the N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801 (0.25 mg/kg IP). MK-801 induced hyperactivity was not detected when rats were observed on days 7, 14 or 21 of 21 daily injections of MK-801. This lack of hyperactivity was also noted 5 days after the last administration of the repeated treatment with MK-801. The hypermotility induced by the D2… CONTINUE READING

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1 Excerpt

1989)oSynergistic blockade of some dopamine-mediated behaviors by (-)-sulpiride and SCH 23390 in the rat

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