Effect of chronic pentobarbital treatment on blood-cerebrospinal fluid kinetics.

Abstract

Cats were made tolerant and physically dependent by twice daily equieffective anesthetic dosing with sodium pentobarbital intragastrically for 5 weeks. Serial blood and CSF samples were simultaneously collected on day 1 and day 35 and analyzed for pentobarbital by a gas chromatographic method. Pentobarbital penetration into CSF was rapid and unchanged by chronic treatment. The concentration in blood and CSF increased significantly with chronic treatment; however, the relative CSF/blood concentration ratios were unchanged.

Cite this paper

@article{Okamoto1975EffectOC, title={Effect of chronic pentobarbital treatment on blood-cerebrospinal fluid kinetics.}, author={Machi Okamoto and Norman Boisse}, journal={European journal of pharmacology}, year={1975}, volume={33 1}, pages={205-9} }