Effect of chronic maternal methadone exposure on perinatal development.

  title={Effect of chronic maternal methadone exposure on perinatal development.},
  author={Ian S. Zagon and P J Mclaughlin},
  journal={Biology of the neonate},
  volume={31 5-6},
The effect of perinatal exposure to methadone on body growth and brain development was studied in rat. Female Sprague-Dawley albino rats received daily intraperitoneal injections of 5 mg/kg dl-methadone-HCl during gestation and lactation. Body weights were reduced in drug-treated mothers during gestation and the first 2 weeks of lactation. No differences in gestation time, litter size, or infant mortality were recorded, however methadone-treated offspring grew more slowly than controls. Weight… CONTINUE READING

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