Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.

@article{Kanaan2007EffectOC,
  title={Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.},
  author={Amjad Kanaan and Robert M. Douglas and Seth L Alper and Walter F. Boron and Gabriel G. Haddad},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={293 3},
  pages={
          R1294-302
        }
}
Several pulmonary and neurological conditions, both in the newborn and adult, result in hypercapnia. This leads to disturbances in normal pH homeostasis. Most mammalian cells maintain tight control of intracellular pH (pH(i)) using a group of transmembrane proteins that specialize in acid-base transport. These acid-base transporters are important in adjusting pH(i) during acidosis arising from hypoventilation. We hypothesized that exposure to chronic hypercapnia induces changes in the… CONTINUE READING

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