Effect of chronic consumption of sodium valproate and melatonin on seizure activity in Krushinskii-Molodkina rats

Abstract

Experiments on Krushinskii-Molodkina rats with hereditary predisposition to audiogenic seizures showed that chronic consumption of aqueous solution of melatonin (50 mg/liter) had no effect on the pattern of seizures induced by 20-fold acoustic stimulation. Sodium valproate (50 mg/liter) insignificantly decreased the seizure response. Combined treatment with… (More)
DOI: 10.1007/s10517-006-0429-0

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