Effect of chronic bradykinin administration on insulin action in an animal model of insulin resistance.

@article{Henriksen1998EffectOC,
  title={Effect of chronic bradykinin administration on insulin action in an animal model of insulin resistance.},
  author={Erik J. Henriksen and S Jacob and Donovan L. Fogt and Guenther J. Dietze},
  journal={The American journal of physiology},
  year={1998},
  volume={275 1 Pt 2},
  pages={R40-5}
}
The nonapeptide bradykinin (BK) has been implicated as the mediator of the beneficial effect of angiotensin-converting enzyme inhibitors on insulin-stimulated glucose transport in insulin-resistant skeletal muscle. In the present study, the effects of chronic in vivo BK treatment of obese Zucker (fa/fa) rats, a model of glucose intolerance and severe insulin resistance, on whole body glucose tolerance and skeletal muscle glucose transport activity stimulated by insulin or contractions were… CONTINUE READING