Effect of chronic bombesin on pancreatic size, composition and secretory function in the rat.

@article{Stockdamge1987EffectOC,
  title={Effect of chronic bombesin on pancreatic size, composition and secretory function in the rat.},
  author={Christiane Stock-damge and Evelyne F. Lhoste and Marc Aprahamian and Annie Pousse},
  journal={Gut},
  year={1987},
  volume={28},
  pages={1 - 7}
}
Bombesin administered subcutaneously to rats, three times daily for four days, induces pancreatic growth at a dose of 10 micrograms/kg. Growth was characterised by an increased pancreatic weight and content in protein and RNA, accompanied by cellular hypertrophy. Chronic bombesin also enhanced the pancreatic content in chymotrypsin and to a lesser degree its contents in amylase and lipase. The volume of the secretion and the output of enzymes in response to CCK under an infusion of secretin… Expand
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TLDR
It is suggested thatBombesin, administered for 5 days in the rat, induces pancreatic growth due to cellular hypertrophy, however the mode of action, at the cellular level, of bombesin appears to be different from that of cholecystokinin. Expand
Trophic effect of bombesin on the rat pancreas: Is it mediated by the release of gastrin or cholecystokinin?
TLDR
It is concluded that chronic bombesin induces, in the rat pancreas, cellular hypertrophy or hyperplasia depending on the duration of treatment, which is not mediated by the release of endogenous gastrin or cholecystokinin. Expand
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TLDR
Repeated injections of cholecystokinin (CCK) during a period of up to 3 weeks significantly increased the weight of the pancreas in rats, suggesting hypertrophy of the acinar cells, and with increase in the total amount of pancreatic DNA, indicating additional hyperplasia of the gland. Expand
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Whether secretin also alters pancreatic growth by itself and whether it influences the trophic response to caerulein, a structural and functional homolog of cholecystokinin, is examined. Expand
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TLDR
It is concluded that the increase in pancreatic weight produced by repeated injections of cholecystokinin was accompanied by proportional increase in functional capacity as reflected by the increased maximal bicarbonate and protein outputs in response to chole Cytokinin. Expand
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TLDR
Synthetic bombesin was infused at low doses in six male volunteers to investigate its effect in man, and concentrations achieved were low enough to indicate a possible physiological role for the endogenous peptide. Expand
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