Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease.

@article{Vita2000EffectOC,
  title={Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease.},
  author={Joseph A. Vita and Alan Yeung and M Winniford and John M. Hodgson and Charles B. Treasure and Jared L Klein and Steven W. Werns and Mark Kern and Donna Plotkin and Weichung Joe Shih and Yale B. Mitchel and Peter A Ganz},
  journal={Circulation},
  year={2000},
  volume={102 8},
  pages={846-51}
}
BACKGROUND Improved endothelial function may contribute to the beneficial effects of cholesterol-lowering therapy. METHODS AND RESULTS In this randomized, double-blind study, we compared the effect of 6 months of simvastatin (40 mg/d) treatment with that of placebo on coronary endothelial vasomotor function in 60 patients with coronary artery disease. Simvastatin lowered LDL-cholesterol by 40+/-12% from 130+/-28 mg/dL (P<0.001). Peak intracoronary acetylcholine infusion produced epicardial… CONTINUE READING
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Simvastatin , an HMGcoenzyme A reductase inhibitor , improves endothelium function within 1 month

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