Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19.

@article{Barrera2015EffectOC,
  title={Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19.},
  author={Francisco Barrera and Lorena Az{\'o}car and Hector Garcia Molina and Kurt Alex Schalper and Marcia Ocares and Jessica Liberona and Luis Antonio Villarroel and Fernando Pimentel and Rosa Mar{\'i}a P{\'e}rez-Ayuso and Flavio Nervi and Albert K. Groen and Juan Francisco Miquel},
  journal={Annals of hepatology},
  year={2015},
  volume={14 5},
  pages={710-21}
}
UNLABELLED Background and rationale for the study. FGF19/15 is a gut-derived hormone presumably governing bile acid (BA) synthesis and gallbladder (GB) refilling. FGF19 mRNA is present in human GB cholangiocytes (hGBECs); however, the physiological significance of GB-derived FGF19 remains unknown. We investigated whether hGBECs secrete FGF19 and the effects of cholecystectomy on serum FGF19 ([FGF19]s) and BA synthesis. MATERIAL AND METHODS FGF19 expression was assessed by qRT-PCRs and… CONTINUE READING
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