Effect of chlorpromazine, reserpine, benactyzine and phenobarbitone on the release of corticotrophin in the rat.

  title={Effect of chlorpromazine, reserpine, benactyzine and phenobarbitone on the release of corticotrophin in the rat.},
  author={Alan Ashford and Maurice Shapero},
  journal={British journal of pharmacology and chemotherapy},
  • A. Ashford, M. Shapero
  • Published 1 December 1962
  • Biology, Medicine
  • British journal of pharmacology and chemotherapy
A single injection into the rat of chlorpromazine, reserpine, benactyzine or phenobarbitone stimulates the release of corticotrophin. This effect is not seen after the drugs have been injected daily for 5 days, nor when the rats are hypophysectomized or pretreated with hydrocortisone. The stimulant effect of ether on corticotrophin release is not modified by pretreatment with a single injection, nor to any great extent after 5 daily injections of these drugs. 
12 Citations
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A survey of literature concerning the effects of psychotherapeutic drugs on pituitary adrenal axis (ACTH-release) in relation to the varieties of acute stress, reveals conflicting views. Central
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The present method for functional hypophysectomy by neck-strangulation in the rat is very simple to perform so that even an experimenter with little experience can become easily accustomed to the technique and obtain a number of functionally hypophyseal tissue preparations at any time he intends, with no need to check the remnant.
Alcohol-Endocrine Interrelationships
The effects of alcohol and alcoholism on endocrine function have received intensive study only in recent years and relatively little data is available on most of the endocrine organs.
ACTH and the effects of anticholinergic drugs in dystonia.
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The effect of reserpine and chlorpromazine on the response of the rat to acute stress.
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  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1958
Both chlorpromazine and reserpine inhibited the response of the rat to acute stress as measured by the degree of adrenal ascorbic acid depletion, suggesting an action on the prepituitary phase of response to stress, possibly on the hypothalamus.
The inhibitory effect of reserpine on ACTH secretion in response to stressful stimuli.
Pharmacologic blockade in the central nervous system, as a means of further clarification of this mechanism, offers certain advantages over the placement of electrolytic lesions.
Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats.
A large dose of reserpine or a prolonged cold-exposure decreased the content of ACTH in the pituitary to such an extent that the animals could not respond to an additional pituitsary stimulus.
The effect of certain central nervous system depressants on pituitary-adrenal activating agents.
The effects of five chemical blocking agents were examined in the rat as to ability to inhibit the adrenal ascorbic acid depleting action of four well known pituitary adrenal activators, finding a common effector site for the activating drugs cannot be assumed.
Effect of chlorpromazine on stress induced adrenal ascorbic acid depletion.
The results on the effects of Dibenzyline, adrenal cortex extract, and morphine on stress induced adrenal ascorbic acid depletion and chlorpromazine on pituitary-adrenal function have been summarized.
Blood ACTH in the stressed adrenalectomized rat after intravenous injection of hydrocortisone.
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Studies on the mechanism of stimulation of ACTH secretion with the aid of morphine as a blocking agent.
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