Effect of chlorpromazine, reserpine, benactyzine and phenobarbitone on the release of corticotrophin in the rat.

@article{Ashford1962EffectOC,
  title={Effect of chlorpromazine, reserpine, benactyzine and phenobarbitone on the release of corticotrophin in the rat.},
  author={Alan Ashford and Maurice Shapero},
  journal={British journal of pharmacology and chemotherapy},
  year={1962},
  volume={19},
  pages={
          458-63
        }
}
  • A. Ashford, M. Shapero
  • Published 1 December 1962
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
A single injection into the rat of chlorpromazine, reserpine, benactyzine or phenobarbitone stimulates the release of corticotrophin. This effect is not seen after the drugs have been injected daily for 5 days, nor when the rats are hypophysectomized or pretreated with hydrocortisone. The stimulant effect of ether on corticotrophin release is not modified by pretreatment with a single injection, nor to any great extent after 5 daily injections of these drugs. 
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References

SHOWING 1-10 OF 11 REFERENCES
The effect of reserpine and chlorpromazine on the response of the rat to acute stress.
  • M. Mahfouz, E. Ezz
  • Chemistry, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1958
TLDR
Both chlorpromazine and reserpine inhibited the response of the rat to acute stress as measured by the degree of adrenal ascorbic acid depletion, suggesting an action on the prepituitary phase of response to stress, possibly on the hypothalamus.
The inhibitory effect of reserpine on ACTH secretion in response to stressful stimuli.
TLDR
Pharmacologic blockade in the central nervous system, as a means of further clarification of this mechanism, offers certain advantages over the placement of electrolytic lesions.
Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats.
TLDR
A large dose of reserpine or a prolonged cold-exposure decreased the content of ACTH in the pituitary to such an extent that the animals could not respond to an additional pituitsary stimulus.
The effect of certain central nervous system depressants on pituitary-adrenal activating agents.
TLDR
The effects of five chemical blocking agents were examined in the rat as to ability to inhibit the adrenal ascorbic acid depleting action of four well known pituitary adrenal activators, finding a common effector site for the activating drugs cannot be assumed.
Effect of chlorpromazine on stress induced adrenal ascorbic acid depletion.
TLDR
The results on the effects of Dibenzyline, adrenal cortex extract, and morphine on stress induced adrenal ascorbic acid depletion and chlorpromazine on pituitary-adrenal function have been summarized.
Blood ACTH in the stressed adrenalectomized rat after intravenous injection of hydrocortisone.
TLDR
The development of a technic for measuring ACTH in blood has made it possible to study ACTH release in the adrenalectomized animal within a few minutes after administration of hydrocortisone.
Studies on the mechanism of stimulation of ACTH secretion with the aid of morphine as a blocking agent.
TLDR
The rapidity with which the pituitary can release adrenocorticotropic hormone (ACTH) in response to various stimuli suggests that the nervous system must play a role in regulatingpituitary function.
Effect of plasma from hypophyseal-portal vessel blood on adrenal ascorbic acid.
TLDR
Although results have varied somewhat, destructive lesions in different sites of the hypothalamus have been reported by several investigators to inhibit the release of ACTH by using pituitary transplants in the rat and rabbit.
Endocrine Pharmacology: Selected Topics
Pharmacology, as the science of the interactions of chemicals with living systems, embraces the study o f hormones, naturally occurring chemicals vital to life and health and often important drugs as
...
1
2
...