Effect of chloroquine on cellular immune responses of normal and P. knowlesi-infected rhesus monkeys.


The immunopharmacokinetics of chloroquine were studied in Plasmodium knowlesi-infected and uninfected rhesus monkeys. In control monkeys, chloroquine depressed the percentage of lymphocyte subpopulation and their proliferative response after the third dose of drug administration. The effect was maximum during day 6 to 10 after initiation of treatment… (More)


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