Effect of chloride channel blockers on the cardiac CFTR chloride and L-type calcium currents.

@article{Walsh1996EffectOC,
  title={Effect of chloride channel blockers on the cardiac CFTR chloride and L-type calcium currents.},
  author={Kenneth B. Walsh and Chengbing Wang},
  journal={Cardiovascular research},
  year={1996},
  volume={32 2},
  pages={391-9}
}
OBJECTIVES The aim of this study was to determine the effects of Cl- channel blockers on the cardiac cystic fibrosis transmembrane conductance regulator (CFTR) Cl- current (ICl) and the protein kinase A-regulated L-type calcium current (PKA-ICa). METHODS Whole-cell ICl and ICa were recorded from isolated guinea pig ventricular myocytes using the patch clamp technique during stimulation of PKA by forskolin (1 or 2 microM). RESULTS The inhibitory effects of clofibric acid, p-chlorophenoxy… CONTINUE READING

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