Effect of chitosan feeding on intestinal bile acid metabolism in rats

  title={Effect of chitosan feeding on intestinal bile acid metabolism in rats},
  author={Yasuhiko Fukada and Koji Kimura and Yoshikazu Ayaki},
The effect of chitosan feeding (for 21 days) on intestinal bile acids was studied in male rats. Serum cholesterol levels in rats fed a commercial diet low in cholesterol were decreased by chitosan supplementation. Chitosan inhibited the transformation of cholesterol to coprostanol without causing a qualitative change in fecal excretion of these neutral sterols. Increased fiber consumption did not increase fecal excretion of bile acids, but caused a marked change in fecal bile acid composition… 

Mechanism study of chitosan on lipid metabolism in hyperlipidemic rats.

It is suggested that chitosan improve lipid metabolism by regulating TC and LDL-C by upregulating of hepatic LDL receptor mRNA expression, increasing the excretion of fecal bile acids.

Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats

The findings suggest that enhancement of hepatic CYP7A1 activity may be a mechanism, which can partially account for the hypocholesterolemic effect of dietary chitosan in cholesterol metabolism.

Dietary chitosan improves hypercholesterolemia in rats fed high-fat diets.

Effect of Dietary Chitin and Chitosan on Cholesterolemia of Rats

5% chitin and/or chitosan addition have not prevented any increase in liver weight or the level of plasma cholesterol and also have not reduced the liver cholesterol content in rats fed enriched lard diet.

Effects of Chitosan on Cholesterol Level and Hepatic Morphology in Ethanol-treated Rats

It is suggested that chitosan improve in vivo lipid metabolism and Potentially protect hepatotoxicity of the rat liver treated with ethanol.

Effect of bile salt hydrolase-active Lactobacillus plantarum Y15 on high cholesterol diet induced hypercholesterolemic mice

ABSTRACT This study aimed to elucidate the underlying mechanisms for the protective effect of Lactobacillus on hypercholesterolemia. Firstly, twenty Lactobacillus strains were screened for potential

Vitamin C increases the fecal fat excretion by chitosan in guinea‐pigs, thereby reducing body weight gain

The results of this study indicated that the fat‐binding and water‐holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion.

Growth performance and intestinal histology in broiler chickens fed with dietary chitosan

It is suggested that a low content of dietary chitosan improved growth performance, and this may be attributed due to the presence of hypertrophied villi and epithelial cells.



The effect of dietary fibre on bile acid metabolism in rats

L Liver microsomal cholesterol 7α-hydroxylase activity was lower in rats fed on the low-fibre and bran- supplemented low-Fibre diets compared with that in rats feeding on the commercial pelleted diet.

A novel use of chitosan as a hypocholesterolemic agent in rats.

A proper supplementation of chitosan to the diet seemed to be effective in lowering plasma cholesterol, and relatively more cholesterol existed as high-density lipiproteins and less as very low- density lipoproteins.

Effects of cholesterol feeding to maternal rats on metabolism of cholesterol and bile acids in the dams and their offspring

The results suggest that the metabolism of cholesterol and of bile acids in dams and their offspring respond differently to cholesterol intake, with a pronounced increase in the pool of β-muricholic acid and a relative decrease in the lithocholic acid concentration in pregnant rats.

Comparative effects of chitosan and cholestyramine on lymphatic absorption of lipids in the rat.

The data suggest that chitosan is as effective as cholestyramine in its acute effects on lipid absorption and that, with chronic feeding, both materials cause equivalent adaptive changes in intestinal transport of administered fatty acid and cholesterol.


There seems to be a general pathway for the metabolism of bile acids irrespective of the species, i.e. the formation of a trihydroxycholanic acid in the liver by degradation of cholesterol, elimination of the hydroxyl at C-7 of this acid, and in some cases hydroxymation by liver enzymes of the deoxycholic acid formed.

Dietary fiber supplementation and fecal bile acids, neutral steroids and divalent cations in rats.

Young adult rats were fed ad libitum on defined diets containing either no fiber, 10% levels of insoluble fiber sources [cellulose, wheat bran, alfalfa, mixed fibers] or 2% cholestyramine (Questran), a bile acid sequestrant, which resulted in significant dilution of total fecal steroids.