Effect of chitosan feeding on intestinal bile acid metabolism in rats

@article{Fukada2006EffectOC,
  title={Effect of chitosan feeding on intestinal bile acid metabolism in rats},
  author={Yasuhiko Fukada and Koji Kimura and Yoshikazu Ayaki},
  journal={Lipids},
  year={2006},
  volume={26},
  pages={395-399}
}
The effect of chitosan feeding (for 21 days) on intestinal bile acids was studied in male rats. Serum cholesterol levels in rats fed a commercial diet low in cholesterol were decreased by chitosan supplementation. Chitosan inhibited the transformation of cholesterol to coprostanol without causing a qualitative change in fecal excretion of these neutral sterols. Increased fiber consumption did not increase fecal excretion of bile acids, but caused a marked change in fecal bile acid composition… 
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53 Citations
Background Citations
18
Methods Citations
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53 Citations

Citation Type

Citation Type

Selective in vivo effect of chitosan on fatty acid, neutral sterol and bile acid excretion: a longitudinal study.
TLDR
Results reveal that chitosan and digestion resistant maltodextrin exert their hypolipidemic activity by different mechanisms.
Mechanism study of chitosan on lipid metabolism in hyperlipidemic rats.
TLDR
It is suggested that chitosan improve lipid metabolism by regulating TC and LDL-C by upregulating of hepatic LDL receptor mRNA expression, increasing the excretion of fecal bile acids.
Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats
TLDR
The findings suggest that enhancement of hepatic CYP7A1 activity may be a mechanism, which can partially account for the hypocholesterolemic effect of dietary chitosan in cholesterol metabolism.
Dietary chitosan improves hypercholesterolemia in rats fed high-fat diets.
TLDR
The results suggest that chitosan reduced the absorption of dietary fat and cholesterol in vivo and could effectively improve hypercholesterolemia in rats.
Effect of Dietary Chitin and Chitosan on Cholesterolemia of Rats
TLDR
5% chitin and/or chitosan addition have not prevented any increase in liver weight or the level of plasma cholesterol and also have not reduced the liver cholesterol content in rats fed enriched lard diet.
Effects of Chitosan on Cholesterol Level and Hepatic Morphology in Ethanol-treated Rats
This study was designed to determine the effect of chitosan on in vivo lipid metabolism in male Sprague-Dawley rats treated with ethanol. Rats were divided into four groups and reared for 6 weeks: E…
Effect of bile salt hydrolase-active Lactobacillus plantarum Y15 on high cholesterol diet induced hypercholesterolemic mice
ABSTRACT This study aimed to elucidate the underlying mechanisms for the protective effect of Lactobacillus on hypercholesterolemia. Firstly, twenty Lactobacillus strains were screened for potential…
Vitamin C increases the fecal fat excretion by chitosan in guinea‐pigs, thereby reducing body weight gain
TLDR
The results of this study indicated that the fat‐binding and water‐holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion.
Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MSs⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of a figure. Published, JLR Papers in Press, September 4, 2008.
TLDR
The method for analyzing BA composition in various tissues and intestinal contents using ultra performance liquid chromatography/electrospray ionization mass spectrometry (UPLC/ESI-MS) established will be useful for investigating the roles of BA metabolism under physiological and pathological conditions.
Lipid-lowering activities of chitosan and its quaternary ammonium salt for the hyperlipidemia rats induced by high-fat diets.
TLDR
The findings indicated that CS and HACC could reduce the absorption of dietary fat and cholesterol in vivo, which helped to alleviate hyperlipidemia and fatty liver effectively in the rats.
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References

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