Effect of chitosan feeding on intestinal bile acid metabolism in rats

@article{Fukada1991EffectOC,
  title={Effect of chitosan feeding on intestinal bile acid metabolism in rats},
  author={Yasuhiko Fukada and Koji Kimura and Yoshikazu Ayaki},
  journal={Lipids},
  year={1991},
  volume={26},
  pages={395-399}
}
The effect of chitosan feeding (for 21 days) on intestinal bile acids was studied in male rats. Serum cholesterol levels in rats fed a commercial diet low in cholesterol were decreased by chitosan supplementation. Chitosan inhibited the transformation of cholesterol to coprostanol without causing a qualitative change in fecal excretion of these neutral sterols. Increased fiber consumption did not increase fecal excretion of bile acids, but caused a marked change in fecal bile acid composition… 
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53 Citations
Background Citations
18
Methods Citations
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53 Citations

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ABSTRACT This study aimed to elucidate the underlying mechanisms for the protective effect of Lactobacillus on hypercholesterolemia. Firstly, twenty Lactobacillus strains were screened for potential…

Vitamin C increases the fecal fat excretion by chitosan in guinea‐pigs, thereby reducing body weight gain

The results of this study indicated that the fat‐binding and water‐holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion.

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It is suggested that a low content of dietary chitosan improved growth performance, and this may be attributed due to the presence of hypertrophied villi and epithelial cells.
...

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