Effect of childhood acute lymphoblastic leukemia therapy on spermatogonia populations and future fertility.

Abstract

CONTEXT Isolation of spermatogonial stem cells before potentially sterilizing cancer therapy, followed by transplantation of these cells into the testis after such treatment, may be an effective approach to prevent infertility among prepubertal boys suffering from acute lymphoblastic leukemia (ALL). A key clinical consideration in this context is the timing… (More)
DOI: 10.1210/jc.2009-0060

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