Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma

@article{Skubitz2019EffectOC,
  title={Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma},
  author={Keith M. Skubitz and Jon D. Wilson and Edward Y Cheng and Bruce R. Lindgren and Kristin L. M. Boylan and Amy P. N. Skubitz},
  journal={Journal of Translational Medicine},
  year={2019},
  volume={17}
}
BackgroundCancer stem cells (CSC) may respond to chemotherapy differently from other tumor cells.MethodsThis study examined the expression of the putative cancer stem cell markers ALDH1, CD44, and CD133; the angiogenesis marker CD31; and the macrophage marker CD68 in soft tissue sarcomas (STS) before and after 4 cycles of chemotherapy with doxorubicin and ifosfamide in 31 patients with high-grade soft tissue sarcoma in a prospective clinical trial.ResultsNone of the markers clearly identified… Expand
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