Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma

  title={Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma},
  author={Keith M. Skubitz and Jon D. Wilson and Edward Y Cheng and Bruce R. Lindgren and Kristin L. M. Boylan and Amy P. N. Skubitz},
  journal={Journal of Translational Medicine},
BackgroundCancer stem cells (CSC) may respond to chemotherapy differently from other tumor cells.MethodsThis study examined the expression of the putative cancer stem cell markers ALDH1, CD44, and CD133; the angiogenesis marker CD31; and the macrophage marker CD68 in soft tissue sarcomas (STS) before and after 4 cycles of chemotherapy with doxorubicin and ifosfamide in 31 patients with high-grade soft tissue sarcoma in a prospective clinical trial.ResultsNone of the markers clearly identified… Expand
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Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
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The CD133+ subpopulation of the SW982 human synovial sarcoma cell line exhibits cancer stem-like characteristics.
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Identification of cancer stem cells in Ewing's sarcoma.
These observations provide the first identification of ESFT cancer stem cells and demonstration of their MSC properties, a critical step towards a better biological understanding and rational therapeutic targeting of these tumors. Expand
Expression of CD133 in Synovial Sarcoma
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The presence of CD133 expressing cells in synovial sarcoma for the first time is demonstrated and the relationship between CD133 expression and cancer stem-like cells suggests thatCD133 expressing synovials may represent cancer stem -like cells insynovial Sarcoma, which has significant implications for understanding the pathogenesis of this tumor and developing effective therapies. Expand
Identification and expansion of the tumorigenic lung cancer stem cell population
Lung cancer contains a rare population of CD133+ cancer stem-like cells able to self-renew and generates an unlimited progeny of non-tumorigenic cells, which may provide valuable information to be exploited in the clinical setting. Expand
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Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies
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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
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