Effect of chemotherapy for acute myelogenous leukemia on hematopoietic and fibroblast marrow progenitors

  title={Effect of chemotherapy for acute myelogenous leukemia on hematopoietic and fibroblast marrow progenitors},
  author={Carmelo Carlo-Stella and Antonio Tabilio and Ester Regazzi and Daniela Garau and R La Tagliata and Stefano Trasarti and Cristina Andrizzi and Marco Vignetti and Giovanna Meloni},
  journal={Bone Marrow Transplantation},
Since reduced marrow cellularity and prolonged pancytopenia following autologous bone marrow transplantation (ABMT) have been frequently observed in patients with acute myelogenous leukemia (AML) included in the AML10 GIMEMA/EORTC trial, the question was raised to what extent hematopoietic and microenvironmental progenitor cells were involved in these patients. Marrow hematopoietic progenitors were investigated by a short-term methylcellulose assay quantitating multipotent CFU-Mix, erythroid… CONTINUE READING
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