Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.

@article{Kandimalla2001EffectOC,
  title={Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.},
  author={Ekambar R. Kandimalla and Donglei Yu and Qiuyan Zhao and Sudhir Agrawal},
  journal={Bioorganic & medicinal chemistry},
  year={2001},
  volume={9 3},
  pages={807-13}
}
Oligodeoxynucleotides containing unmethylated CpG-motifs stimulate the innate immune system, including inducing B-cell proliferation and cytokine production. However, the mechanism of immunostimulation by CpG-oligonucleotides and the precise structural requirements and specific functional groups of cytosine and guanine necessary for recognition of and interaction with protein/receptor factors that are responsible for immune stimulation have not been elucidated. We sought to understand the… CONTINUE READING
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