Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.

@article{Cohen2001EffectOC,
  title={Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.},
  author={Ofer Cohen and Chanoch Kronman and Theodor Chitlaru and Arie Ordentlich and Baruch Velan and Avigdor Shafferman},
  journal={The Biochemical journal},
  year={2001},
  volume={357 Pt 3},
  pages={795-802}
}
Post-translational modifications were recently shown to be responsible for the short circulatory mean residence time (MRT) of recombinant human acetylcholinesterase (rHuAChE) [Kronman, Velan, Marcus, Ordentlich, Reuveny and Shafferman (1995) Biochem. J. 311, 959--967; Chitlaru, Kronman, Zeevi, Kam, Harel, Ordentlich, Velan and Shafferman (1998) Biochem. J. 336, 647--658; Chitlaru, Kronman, Velan and Shafferman (2001) Biochem. J. 354, 613--625], which is one of the major obstacles to the… CONTINUE READING

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Structure of recombinant native and E 202 Q mutant human acetylcholinesterase complexed with the snake venom toxin fasciculinII

  • G. Kryger, M. Harel, +7 authors A. Shafferman
  • Acta Crystallogr . , Sect . D : Biol…
  • 2000

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