Effect of chemical ablation of myenteric neurons on neurotransmitter levels in the rat jejunum.

@article{Dahl1987EffectOC,
  title={Effect of chemical ablation of myenteric neurons on neurotransmitter levels in the rat jejunum.},
  author={June L. Dahl and D D Bloom and Miles L. Epstein and Darrell Fox and Paul Bass},
  journal={Gastroenterology},
  year={1987},
  volume={92 2},
  pages={338-44}
}
We have quantified neurotransmitter changes in the rat jejunum in which the myenteric neurons were ablated by serosal application of benzalkonium chloride. Within 2 days after benzalkonium chloride treatment, there was a 40% reduction in the activity of choline acetyltransferase, a specific marker for cholinergic neurons, and a 25% reduction in the amount of vasoactive intestinal peptide per centimeter length of jejunum. By 15 days, levels were comparable to those in control segments, and by 45… CONTINUE READING

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