Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.

  title={Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.},
  author={Vladislav Eybl and Dana Kotyzov{\'a} and Jaroslav Koutensk{\'y} and M. M. Jones and P. K. Singh},
  journal={The Analyst},
  volume={120 3},
In experiments performed on male mice (ICR) the mobilizing effect of monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) and a dithiocarbamate analogue, N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbod ithioate (MeBLDTC) on the cadmium deposits was studied. The influence of these compounds on the changes in the level of essential elements caused by cadmium was explored. CdCl2.H2O was injected intravenously. The chelators were administered every 48 h over 12 d. Both compounds… Expand
Effect of cadmium chelating agents on organ cadmium and trace element levels in mice.
In experiments performed on male mice, the mobilizing effects of repeated administration of the carbodithioate analogue BLDTC and CaDTPA on cadmium deposits in the liver, kidneys, brain and testes were compared and confirmedBLDTC to be one of the most effective Cadmium mobilizing agents. Expand
Chemistry and developments of N-thiocarbonyl carbohydrate derivatives: Sugar isothiocyanates, thioamides, thioureas, thiocarbamates, and their conjugates
Publisher Summary This chapter discusses the chemistry and developments of N -thiocarbonyl carbohydrate derivatives. In N -thiocarbonyl compounds, conjugation of the π-system of the C=S group and theExpand
On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview
Cadmium (Cd) has been classified as a human carcinogen. The World Health Organization (WHO) reported that the concentration of Cd in the environment has rapidly increased in the last few years. InExpand
Effect of supplemental magnesium on the kidney levels of cadmium, zinc, and copper of mice exposed to toxic levels of cadmium
Under the condition of subacute Cd intoxication, Mg supplementation reduced Cd kidney content after 2 wk for about 30%, compared with animals treated with Cd only and the effect of Mg on Cu and Zn kidney content was also beneficial. Expand
Trace Elements Status in Selenium-Deficient Rats—Interaction with Cadmium
Selenium-deficient rats of both genders showed significantly lower accumulation of cadmium in the liver, compared to Se-adequate rats, and Cadmium supplementation increased zinc and decreased iron hepatic level, regardless of Se status and decreased copper concentration in Se- inadequate rats. Expand
Chelation Treatment During Acute and Chronic Metal Overexposures: Experimental and Clinical Studies
Metal overexposures, ranging from nonsymptomatic, elevated body levels to life threatening acute or chronic poisonings, should in general be treated by eliminating the exposure source, by variousExpand
Heavy Metal Poisoning and its Laboratory Investigation
The intention in this review is to provide an overview of some general concepts of metal toxicology and to discuss in detail metals of particular importance, namely, cadmium, lead, mercury, thallium, bismuth, arsenic, antimony and tin. Expand
Agency for Toxic Substances and Disease Registry.
  • Foreword
  • Medicine
  • Asian American and Pacific Islander journal of health
  • 1997
The mission of the Agency for Toxic Substances and Disease Registry (ATSDR) is to prevent or mitigate the adverse human health effects and diminished quality of life that result from exposure toExpand


Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.
The monoisoamyl ester was the most effective in removing cadmium from both the liver and the kidneys when given orally and is the first compound which is reported capable of mobilizing Cadmium in vivo from aged deposits after oral administration. Expand
Comparative effects of three chelating agents on distribution and excretion of cadmium in rats.
The results of this study reveal that the injection of NBG-DTC to rats pretreated with cadmium can more effectively remove Cadmium from the body without the mobilization of cadmiam to the kidney, the critical organ in cadmia toxicity, and without redistribution of cadMium to other tissues such as brain, testes, and heart. Expand
Comparison of the Effects of Sodium N-Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice
The administration of sodium N-benzyl-D-glucamine dithiocarbamate (N-BG-DC) to rats pretreated with cadmium can effectively remove cadmium from the body (Kojima et al. 1986 a, b). The purpose of theExpand
Effect of dithiocarbamates and dithiocarbamate-induced cadmium mobilization on essential trace metal metabolism in the female rat
Abstract The effects of two dithiocarbamates (both of which induce an increase in the excretion of cadmium) on the biliary and urinary excretion of the essential trace elements zinc, copper, iron,Expand
Dithiocarbamates of improved efficacy for the mobilization of retained cadmium from renal and hepatic deposits.
An examination of the structural features of the more effective compounds for the mobilization of cadmium from its aged deposits reveals that the combination of a high molecular weight with a suitable amphipathic structure in which the polar and non-polar groups are in an appropriate balance are key features. Expand
Effect of N-benzyl-D-glucamine dithiocarbamate on the renal toxicity produced by subacute exposure to cadmium in rats.
The results of this study indicate that BGD treatment is effective in decreasing the cadmium concentrations in liver and kidney, resulting in the therapeutic effect on the Cadmium-induced renal damage. Expand
Interaction of chelating agents with cadmium in mice and rats.
It was demonstrated that the combined application of the antidotes showed little or no improvement over the results obtained with the most effective of the individual components. Expand