Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.

@article{Eybl1995EffectOC,
  title={Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.},
  author={Vladislav Eybl and Dana Kotyzov{\'a} and Jaroslav Koutensk{\'y} and M. M. Jones and P. K. Singh},
  journal={The Analyst},
  year={1995},
  volume={120 3},
  pages={
          855-7
        }
}
In experiments performed on male mice (ICR) the mobilizing effect of monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) and a dithiocarbamate analogue, N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbod ithioate (MeBLDTC) on the cadmium deposits was studied. The influence of these compounds on the changes in the level of essential elements caused by cadmium was explored. CdCl2.H2O was injected intravenously. The chelators were administered every 48 h over 12 d. Both compounds… Expand
Effect of cadmium chelating agents on organ cadmium and trace element levels in mice.
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Chemistry and developments of N-thiocarbonyl carbohydrate derivatives: Sugar isothiocyanates, thioamides, thioureas, thiocarbamates, and their conjugates
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TLDR
The monoisoamyl ester was the most effective in removing cadmium from both the liver and the kidneys when given orally and is the first compound which is reported capable of mobilizing Cadmium in vivo from aged deposits after oral administration. Expand
Comparative effects of three chelating agents on distribution and excretion of cadmium in rats.
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The results of this study reveal that the injection of NBG-DTC to rats pretreated with cadmium can more effectively remove Cadmium from the body without the mobilization of cadmiam to the kidney, the critical organ in cadmia toxicity, and without redistribution of cadMium to other tissues such as brain, testes, and heart. Expand
Comparison of the Effects of Sodium N-Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice
The administration of sodium N-benzyl-D-glucamine dithiocarbamate (N-BG-DC) to rats pretreated with cadmium can effectively remove cadmium from the body (Kojima et al. 1986 a, b). The purpose of theExpand
Effect of dithiocarbamates and dithiocarbamate-induced cadmium mobilization on essential trace metal metabolism in the female rat
Abstract The effects of two dithiocarbamates (both of which induce an increase in the excretion of cadmium) on the biliary and urinary excretion of the essential trace elements zinc, copper, iron,Expand
Dithiocarbamates of improved efficacy for the mobilization of retained cadmium from renal and hepatic deposits.
TLDR
An examination of the structural features of the more effective compounds for the mobilization of cadmium from its aged deposits reveals that the combination of a high molecular weight with a suitable amphipathic structure in which the polar and non-polar groups are in an appropriate balance are key features. Expand
Effect of N-benzyl-D-glucamine dithiocarbamate on the renal toxicity produced by subacute exposure to cadmium in rats.
TLDR
The results of this study indicate that BGD treatment is effective in decreasing the cadmium concentrations in liver and kidney, resulting in the therapeutic effect on the Cadmium-induced renal damage. Expand
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TLDR
It was demonstrated that the combined application of the antidotes showed little or no improvement over the results obtained with the most effective of the individual components. Expand