Effect of chang run tong on the biomechanical and morphometric remodeling of colon and rectum in streptozotocin-induced diabetic rats

@article{Sha2013EffectOC,
  title={Effect of chang run tong on the biomechanical and morphometric remodeling of colon and rectum in streptozotocin-induced diabetic rats},
  author={Hongyu Sha and Dong Zhao and Jingbo Zhao and Guifang Liu and Zhong Zhen and Peng-min Chen and Xiaolin Tong and Hans Gregersen},
  journal={Journal of Medical and Biological Engineering},
  year={2013},
  volume={33},
  pages={149-154}
}
The present study investigates the effect of Chang Run Tong (CRT) on the biomechanical and morphometrical remodeling of colon and rectum in streptozotocin-induced diabetic rats. The colonic and rectal segments were obtained from diabetic (DM), CRT-treated diabetic (T1, high dosage: 50 g/kg/day; T2, low dosage: 25 g/kg/day) and normal (Con) rats. The experimental period was 60 d. The blood glucose level and body weight were measured. The circumferential length, wall thickness, and opening angle… 
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Figures from this paper

Abnormal expressions of AGEs, TGF-β1, BDNF and their receptors in diabetic rat colon–Associations with colonic morphometric and biomechanical remodeling
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Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats
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The corrective effect on the expressions of those proteins is likely to be one molecular pathway for the improvement of CRT on the diabetes-induced colon remodeling.

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