Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes.

@article{Janov2011EffectOC,
  title={Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes.},
  author={Barbora Janů{\vs}ov{\'a} and Jarmila Zbytovsk{\'a} and Petr Lorenc and Helena Vavrysov{\'a} and Karel Palat and Alexandr Hrab{\'a}lek and Kateřina V{\'a}vrov{\'a}},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1811 3},
  pages={129-37}
}
Stratum corneum ceramides play an essential role in the barrier properties of skin. However, their structure-activity relationships are poorly understood. We investigated the effects of acyl chain length in the non-hydroxy acyl sphingosine type (NS) ceramides on the skin permeability and their thermotropic phase behavior. Neither the long- to medium-chain ceramides (8-24 C) nor free sphingosine produced any changes of the skin barrier function. In contrast, the short-chain ceramides decreased… CONTINUE READING