Effect of central nicotinic activation on drinking behavior.

  title={Effect of central nicotinic activation on drinking behavior.},
  author={Kentaro Ono and Masaki Hirase and Aya Kai and Kiyotoshi Inenaga},
  volume={19 8},
Intracerebroventricular injections of angiotensin II (ANG) and nicotine activate the subfornical organ (SFO), an essential central nucleus for ANG-induced drinking. Nicotine has been, however, reported to induce little drinking behavior. To clarify this paradox, we investigated effects of nicotine and ANG on activity of SFO neurons and drinking behavior. In extracellular recordings many SFO neurons (57%) were excited by the both drugs. The nicotine-induced excitation was transient, whereas the… CONTINUE READING
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