Effect of central muscarine receptor blockade with DKJ-21 on the blood pressure and heart rate in stress-induced hypertensive rats.

@article{Zhu1996EffectOC,
  title={Effect of central muscarine receptor blockade with DKJ-21 on the blood pressure and heart rate in stress-induced hypertensive rats.},
  author={D N Zhu and L M Xue and P. Li},
  journal={Blood pressure},
  year={1996},
  volume={5 3},
  pages={
          170-7
        }
}
The experiments were performed on Wistar or Sprague-Dawley rats of both sexes divided at random into stress and control groups. The rats in the stress groups were put into cages and subjected to electric foot-shocks and noises for 9-15 days, which caused an increase in blood pressure (BP) and heart rate (HR). In hypertensive rats DKJ-21 (4 mg/1 ml) was injected intravenously (i.v.), and 0.5-1.0 h after administration the BP and HR dropped from the high level to normotensive level. In… 
Stress, the Hypothalamo-Pituitary-Adrenal System, and the Heart
TLDR
The cardiovascular system signals stress influences on humans and other animals and the other major stress system of the body, the hypothalamic-pituitary-adrenal system, is focused on as the messenger of stress effects to the heart.

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