Effect of cellular senescence on the growth of HER2-positive breast cancers.

  title={Effect of cellular senescence on the growth of HER2-positive breast cancers.},
  author={Mariano Federico Zacar{\'i}as-Fluck and Beatriz Morancho and Rocio Vicario and Antonio Luque Garcia and Marta Escorihuela and Josep Villanueva and Isabel Teresa Rubio and Joaqu{\'i}n Arribas},
  journal={Journal of the National Cancer Institute},
  volume={107 5}
BACKGROUND Oncogene-induced senescence (OIS) is a tumor suppressor mechanism. However, senescent cells remain viable and display a distinct secretome (also known as senescence-associated secretory phenotype [SASP] or senescence messaging secretome, [SMS]) that, paradoxically, includes protumorigenic factors. OIS can be triggered by ectopic overexpression of HER2, a receptor tyrosine kinase and the driving oncogene in a subtype of human breast cancer. However, cellular senescence has not been… CONTINUE READING
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