Effect of cell polarization on hepatitis C virus entry.

  title={Effect of cell polarization on hepatitis C virus entry.},
  author={Christopher J. Mee and Joe Grove and Helen J. Harris and Ke Hu and Peter Balfe and Jane A McKeating},
  journal={Journal of virology},
  volume={82 1},
The primary reservoir for hepatitis C virus (HCV) replication in vivo is believed to be hepatocytes within the liver. Three host cell molecules have been reported to be important entry factors for receptors for HCV: the tetraspanin CD81, scavenger receptor BI (SR-BI), and the tight-junction (TJ) protein claudin 1 (CLDN1). The recent discovery of a TJ protein as a critical coreceptor highlighted the importance of studying the effect(s) of TJ formation and cell polarization on HCV entry. The… CONTINUE READING


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Role of Polarization in Hcv Entry

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