Effect of cell-cycle position and dose on the kinetics of DNA double-strand breakage repair in X-irradiated Chinese hamster cells.

@article{Radford1987EffectOC,
  title={Effect of cell-cycle position and dose on the kinetics of DNA double-strand breakage repair in X-irradiated Chinese hamster cells.},
  author={Ian R Radford},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1987},
  volume={52 4},
  pages={555-64}
}
  • Ian R Radford
  • Published 1987 in
    International journal of radiation biology and…
The kinetics of DNA double-strand breakage (d.s.b.) repair in X-irradiated Chinese hamster V79 cells were found to be affected by cell-cycle position. In mitotic cells, the repair kinetics were monophasic with a half-time value of about 32 min, whilst in G1, S, or asynchronous cultures, the kinetics were biphasic with half-time values of around 2.7 and 27 min. The repair of DNA single-strand breakage (s.s.b) was also shown to be slower in mitotic than in interphase cells. The DNA d.s.b. repair… CONTINUE READING

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