Effect of celecoxib on cardiovascular events and blood pressure in two trials for the prevention of colorectal adenomas.

@article{Solomon2006EffectOC,
  title={Effect of celecoxib on cardiovascular events and blood pressure in two trials for the prevention of colorectal adenomas.},
  author={Scott Solomon and Marc Pfeffer and John J V McMurray and Rob Fowler and Peter Finn and Bernard Levin and Craig J. Eagle and Ernest Hawk and Mariajos{\'e} Lechuga and Ann Graham Zauber and Monica M. Bertagnolli and Nadir Arber and Janet Wittes},
  journal={Circulation},
  year={2006},
  volume={114 10},
  pages={1028-35}
}
BACKGROUND Cyclooxygenase-2 (COX-2) inhibitors have been shown to reduce colorectal adenomas but have been associated with increased cardiovascular risk. METHODS AND RESULTS The Adenoma Prevention With Celecoxib (APC) trial studied celecoxib 200 mg twice daily and 400 mg twice daily and the Prevention of Spontaneous Adenomatous Polyps (PreSAP) trial used 400 mg once daily totest the efficacy and safety of celecoxib against placebo in reducing colorectal adenoma recurrence after polypectomy… CONTINUE READING

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References

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Development of resistance to selective cyclooxygenase-2 inhibition in C57BL/ 6J-Min/ (Min/ ) mice

AM Carothers, AE Moran, NL Cho, M Redston, MM. Bertagnolli
Cancer Res • 2006

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