Effect of cationic amino acid, L-lysine and its polymers on the growth and secretion of hybridoma cell line OKT-3.

@article{Datta2000EffectOC,
  title={Effect of cationic amino acid, L-lysine and its polymers on the growth and secretion of hybridoma cell line OKT-3.},
  author={Debajyoti Datta and Prabuddha Kumar Kundu and Sanjib Kumar Biswas and Shashiprabha Dasgupta and Akshay Bhinge and Vidya Chandran},
  journal={Hybridoma},
  year={2000},
  volume={19 4},
  pages={
          339-46
        }
}
Apart from their pivotal roles in anabolic protein synthesis, cationic amino acids, particularly, L-lysine HCl and its oligomers, up to molecular weight 1000, showed a remarkable property of cellular growth stimulation both in vitro and in vivo. L- and D-Lysine HCl, at a maximal stimulatory concentration of 7 microg/mL of added load of the amino acid, supported a characteristic time-scaled cellular expansion in vitro, and L-lysine-mediated cell expansion in batch cultures always showed a… CONTINUE READING