Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats.

@article{Hayashi1996EffectOC,
  title={Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats.},
  author={Naoki Hayashi and Daiji Yoshihara and Norio Kashiwabara and Yasuyoshi Takeshita and Harumi Handa and Mitsuru Yamakawa},
  journal={Biological \& pharmaceutical bulletin},
  year={1996},
  volume={19 1},
  pages={
          157-9
        }
}
Blood concentrations of branched chain amino acids (BCAA; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis. We investigated the effect of carnitine on serum concentrations of BCAA and Gln in fasted septic rats. Rats were made septic by cecal ligation and puncture. They developed extremely high blood concentrations of endotoxin, and serum concentrations of BCAA and Gln were markedly decreased 2 d after the operation. When L-carnitine was administered… 

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