Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species.

Abstract

Studies were designed to investigate various anions and their effects on cytochrome P450 2D6-mediated metabolism in vitro. Incubations were initially performed in buffered phosphate, carbonate, sulfate, and acetate solutions (50mM, pH 7.4), with CYP2D6 substrates dextromethorphan, 7-methoxy-4-(aminomethyl)-coumarin (MAMC), (S,S)-3-[3-(methylsulfonyl)phenyl… (More)

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@article{Hutzler2003EffectOC, title={Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species.}, author={James Matthew Hutzler and Frank J Powers and Michael A Wynalda and Larry C. Wienkers}, journal={Archives of biochemistry and biophysics}, year={2003}, volume={417 2}, pages={165-75} }