Effect of carbogen breathing and acetazolamide on optic disc PO2.

  title={Effect of carbogen breathing and acetazolamide on optic disc PO2.},
  author={Ioannis K. Petropoulos and Jean-Antoine C. Pournaras and Jean-Luc Munoz and Constantin Jean Pournaras},
  journal={Investigative ophthalmology & visual science},
  volume={46 11},
PURPOSE Acetazolamide was previously shown to increase optic disc partial pressure of oxygen (PO(2)). The study was conducted to evaluate optic disc PO(2) variations during normoxia, hyperoxia (100% O(2)), and carbogen breathing (95% O(2), 5% CO(2)), before and after intravenous administration of acetazolamide. METHODS PO(2) measurements were obtained at intervascular areas of the optic disc in nine anesthetized minipigs using oxygen-sensitive microelectrodes (10-microm tip diameter) placed… CONTINUE READING


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