Effect of carbamazepine therapy on vitamin D and parathormone in epileptic children.

@article{Misra2010EffectOC,
  title={Effect of carbamazepine therapy on vitamin D and parathormone in epileptic children.},
  author={Abhijit Misra and Anju Aggarwal and O Singh and Sangeeta Sharma},
  journal={Pediatric neurology},
  year={2010},
  volume={43 5},
  pages={
          320-4
        }
}

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References

SHOWING 1-10 OF 26 REFERENCES

Effects of Anticonvulsant Therapy on Vitamin D Status in Children: Prospective Monitoring Study

Evidence is provided that carbamazepine or sodium valproate can cause hypovitaminosis D in children and the effects of seasonality on serum 25-hydroxyvitamin D, parathyroid hormone, and calcium were noticed in patients grouped in classes 0, 2 and 3, as well as in controls.

Adverse effects of antiepileptic drugs on bone mineral density.

Long-term anticonvulsant therapy and vitamin D metabolism in ambulatory pubertal children.

Routine vitamin D supplementation does not appear to be indicated in children on anticonvulsant therapy, and parameters of calcium metabolism were thoroughly examined, indicating that anticonVulsant drugs alter significantly the vitamin D metabolism.

Bone Mineral Status in Pediatric Outpatients on Antiepileptic Drug Monotherapy

Assessment of longitudinally bone mineral status in pediatric outpatients on antiepileptic drug monotherapy found osteopenia was not attributed to a defect in serum active vitamin D production owing to hyperparathyroidism in children on antiespecific drug mon therapy.

Prevalence and treatment of vitamin D deficiency in children on anticonvulsant drugs

In a residential home in southeast England the increased nutritional requirement for vitamin D caused by the administration of anticonvulsants to adolescent epileptic children was of the order of 10 μg cholecalciferol per day.

Effect of vitamin D2 and D3 on bone‐mineral content in carbamazepine‐treated epileptic patients

It is concluded that epileptic patients on carbamazepine monotherapy have normal bone metabolism and the biochemical indices of bone metabolism were virtually unchanged during the treatment period.

A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy

Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy.

Residents of an institution for the developmentally disabled in northwest Ohio receiving anticonvulsant therapy for six months or more with phenobarbital or phenytoin or both were studied for the

Evaluation of Bone Mineral Metabolism in Children Receiving Carbamazepine and Valproic Acid

The results suggest that valproic acid and carbamazepine monotherapies have minimal effects on bone mineral metabolism, but routine monitoring of risk and consideration of prophylactic vitamin D supplementation is important.

Does Carbamazepine Treatment Lead to a Need of Extra Vitamin D in some Mentally Retarded Children?

A possibility of hypovitamino‐sis D should be considered in patients on a long‐term carbamazepine therapy, especially if other risks for vitamin D deficiency exist.