Effect of capsianoside, a diterpene glycoside, on tight-junctional permeability.

@article{Hashimoto1997EffectOC,
  title={Effect of capsianoside, a diterpene glycoside, on tight-junctional permeability.},
  author={Kimiko Hashimoto and Hirokazu Kawagishi and Takashi Nakayama and Makoto Shimizu},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1323 2},
  pages={281-90}
}
Previous work (Hashimoto et al., (1994) Biosci. Biotech. Biochem. 58, 1345) revealed that a sweet pepper extract enhanced the tight-junctional (TJ) permeability of a human intestinal Caco-2 cell monolayer. In the present study, the substance which modulated the TJ permeability was chromatographically purified from the extract. The active substances were identified as capsianosides A-F, diterpene glycosides. Treatment of the cells with capsianoside F, the most active compound, decreased the… CONTINUE READING