Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects

  title={Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects},
  author={Manuela P Lejeune and Eva M. R. Kovacs and Margriet S. Westerterp-Plantenga},
  journal={British Journal of Nutrition},
  pages={651 - 659}
The aim of the present study was to investigate whether capsaicin assists weight maintenance by limiting weight regain after weight loss of 5 to 10%. In this randomized double-blind placebo-controlled study, ninety-one moderately overweight subjects were randomly assigned to an intensive group that underwent all the measurements, and an extensive group that underwent the same measurements except the metabolism measurements. After a 4-week very-low-energy diet (VLED) intervention, a 3-month… 

Capsaicinoids supplementation decreases percent body fat and fat mass: adjustment using covariates in a post hoc analysis

Results suggest potential benefits of Capsaicinoids (CAPs) on body fat and fat mass in post hoc analysis and suggest further studies are required to explore pharmacological, physiological, and metabolic benefits of both chronic and acute CAPs consumption.

Prolonged refeeding improves weight maintenance after weight loss with very-low-energy diets

Overall, longer refeeding duration after successful weight loss with a VLED improves weight maintenance in a 1-year perspective.

Addition of capsaicin and exchange of carbohydrate with protein counteract energy intake restriction effects on fullness and energy expenditure.

It is suggested that protein and capsaicin, consumed singly or mixed, counteracted the energy intake restriction effects on fullness and EE and promoted a negative fat balance and protein treatments also prevented a negative protein balance.

Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance

In an effectively 20.5% negative energy balance, consumption of 2.56 mg capsaicin per meal supportsnegative energy balance by counteracting the unfavorable negative energy Balance effect of decrease in components of energy expenditure.

Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)

A capsinoids intake would be able to enhance the energy expenditure and fat burning in humans, particularly those with high BMI.

Effect of capsinoids on energy metabolism in human subjects

Capsinoids provided in four doses did not affect metabolic rate and fuel partitioning in human subjects when measured 2 h after exposure, and longer exposure and higher capsinoids doses may be required to cause meaningful acute effects on energy metabolism.

An Examination of a Novel Weight Loss Supplement on Anthropometry and Indices of Cardiovascular Disease Risk

Ingestion of thermogenic supplements containing DG (300 mg/d) with and without caffeine and other nutrients in overweight but otherwise healthy participants who did not alter diet or physical activity promoted clinically insignificant changes in body weight and composition.

Thermogenic ingredients and body weight regulation

Thermogenic ingredients may be considered as functional agents that could help in preventing a positive energy balance and obesity.



Predictors of weight maintenance.

Physiological (deltaRMR-24 hours) and behavioral factors (previous frequency of dieting and hunger score) predicted failure of weight maintenance and can be used to identify women who are at risk for weight regain.

The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance

Although additional supplementation of CHO, chromium, dietary fibre and caffeine intake did not affect BW, the En”% CHO daily was increased significantly, and this indicates that a high En % intake of CHO and a low En’s intake of fat daily is beneficial for prevention of weight regain.

Effects of capsaicin on lipid metabolism in rats fed a high fat diet.

It is suggested that capsaicin stimulates lipid mobilization from adipose tissue and lowers the perirenal adiposity tissue weight and serum triglyceride concentration in lard-fed rats.

Two year maintenance of weight loss after a VLCD and behavioural therapy for obesity: correlation to the scores of questionnaires measuring eating behaviour.

  • T. PekkarinenI. TakalaP. Mustajoki
  • Medicine, Psychology
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1996
VLCD combined with behaviour modification is a useful mode of therapy for obesity with low drop-out rate and majority of patients below pretreatment weight at the two-year control.

Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ.

It is concluded that in Pima Indians fed a standard diet 1) family membership is the principal determinant of the ratio of fat to carbohydrate oxidation, and 2) a low ratio of fats to carbohydrates is associated with subsequent weight gain independent of low energy expenditure and may contribute to the familial aggregation of obesity.

Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber

In lean women, satiety and DIT were synchronously higher with a high protein/high carbohydrate diet than with ahigh fat diet, and differences in DIT correlated with differences in satiety over 24 h.

Effects of red-pepper diet on the energy metabolism in men.

The results suggest than an increase in the energy expenditure after the meal containing red pepper appeared only immediately after the Meal ingestion and a red-pepper diet increases the carbohydrate oxidation without increasing total energy expenditure for 150 min after the meals.

Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging.

  • J. SeidellD. MullerJ. SorkinR. Andres
  • Medicine
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1992
It was concluded that a relatively high fasting RER is a weak but significant predictor of substantial weight gain in non-obese white men.

Improved reporting of habitual food intake after confrontation with earlier results on food reporting

In the studied group of highly motivated lean women, under-reporting of habitual food intake (here due to undereating) could be eliminated by confrontation with the results of this phenomenon.