Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

  title={Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence},
  author={M. Colizzi and P. McGuire and R. Pertwee and S. Bhattacharyya},
  journal={Neuroscience & Biobehavioral Reviews},
  • M. Colizzi, P. McGuire, +1 author S. Bhattacharyya
  • Published 2016
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • Use of cannabis or delta-9-tetrahydrocannabinol (Δ9-THC), its main psychoactive ingredient, is associated with psychotic symptoms or disorder. However, the neurochemical mechanism that may underlie this psychotomimetic effect is poorly understood. Although dopaminergic dysfunction is generally recognized as the final common pathway in psychosis, evidence of the effects of Δ9-THC or cannabis use on dopaminergic measures in the brain is equivocal. In fact, it is thought that cannabis or Δ9-THC… CONTINUE READING
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