Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence
@article{Colizzi2016EffectOC, title={Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence}, author={M. Colizzi and P. McGuire and R. Pertwee and S. Bhattacharyya}, journal={Neuroscience & Biobehavioral Reviews}, year={2016}, volume={64}, pages={359-381} }
Use of cannabis or delta-9-tetrahydrocannabinol (Δ9-THC), its main psychoactive ingredient, is associated with psychotic symptoms or disorder. However, the neurochemical mechanism that may underlie this psychotomimetic effect is poorly understood. Although dopaminergic dysfunction is generally recognized as the final common pathway in psychosis, evidence of the effects of Δ9-THC or cannabis use on dopaminergic measures in the brain is equivocal. In fact, it is thought that cannabis or Δ9-THC… CONTINUE READING
Paper Mentions
76 Citations
The neuropsychopharmacology of cannabis: A review of human imaging studies
- Medicine
- Pharmacology & therapeutics
- 2019
- 63
- PDF
Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity
- Chemistry, Medicine
- European Neuropsychopharmacology
- 2019
- 12
- PDF
Do the effects of cannabis on the hippocampus and striatum increase risk for psychosis?
- Medicine
- Neuroscience & Biobehavioral Reviews
- 2020
- 1
Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis
- Medicine
- Molecular Psychiatry
- 2019
- 25
- PDF
Modulatory effects of cannabinoids on brain neurotransmission
- Medicine
- The European journal of neuroscience
- 2019
- 24
Adolescent‐onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus
- Medicine
- Addiction biology
- 2019
- 6
Neurocognitive effects of cannabis: Lessons learned from human experimental studies.
- Medicine
- Progress in brain research
- 2018
- 8
Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex
- Psychology, Medicine
- Psychopharmacology
- 2017
- 15
- PDF
Does Cannabis Composition Matter? Differential Effects of Delta-9-tetrahydrocannabinol and Cannabidiol on Human Cognition
- Psychology, Medicine
- Current Addiction Reports
- 2017
- 64
- PDF
Modulation of acute effects of delta-9-tetrahydrocannabinol on psychotomimetic effects, cognition and brain function by previous cannabis exposure
- Medicine
- European Neuropsychopharmacology
- 2018
- 10
- PDF
References
SHOWING 1-10 OF 96 REFERENCES
Does cannabis affect dopaminergic signaling in the human brain? A systematic review of evidence to date
- Psychology, Medicine
- European Neuropsychopharmacology
- 2015
- 48
Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines
- Psychology, Medicine
- Schizophrenia Research
- 2010
- 102
Neural mechanisms for the cannabinoid modulation of cognition and affect in man: a critical review of neuroimaging studies.
- Medicine
- Current pharmaceutical design
- 2012
- 53
Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing.
- Psychology, Medicine
- Archives of general psychiatry
- 2012
- 165
- PDF
Towards a glutamate hypothesis of depression: An emerging frontier of neuropsychopharmacology for mood disorders
- Psychology, Medicine
- Neuropharmacology
- 2012
- 664
Cannabinoid Modulation of Functional Connectivity within Regions Processing Attentional Salience
- Psychology, Medicine
- Neuropsychopharmacology
- 2015
- 78
Imaging the neural effects of cannabinoids: current status and future opportunities for psychopharmacology.
- Medicine
- Current pharmaceutical design
- 2009
- 47
Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling
- Biology, Medicine
- Cell
- 2013
- 74
- Highly Influential
- PDF
Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats
- Psychology, Medicine
- Neurobiology of Disease
- 2014
- 91
- Highly Influential
Impairment of inhibitory control processing related to acute psychotomimetic effects of cannabis
- Psychology, Medicine
- European Neuropsychopharmacology
- 2015
- 51