Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex

@article{Revuelta1978EffectOC,
  title={Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex},
  author={A. V. Revuelta and Flavio Moroni and Dorothy L Cheney and Erminio Costa},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1978},
  volume={304},
  pages={107-110}
}
The effects of Δ9-tetrahydrocannabinol, (Δ9THC) the major psychoactive compound of marijuana, and cannabidiol (CBD), a non-psychoactive component, on the acetylcholine (ACh) concentration and the turnover rate of ACh (TRACh) have been studied in various regions of the rat brain. Neither Δ9THC doses from 0.2 to 10 mg/kg nor CBD (10 or 20 mg/kg) alter the ACh concentration in the brain areas examined 30 min, after the intravenous injection. However, Δ9-THC (doses from 0.2 to 10 mg/kg) causes a… CONTINUE READING

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